Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival
نویسندگان
چکیده
BACKGROUND It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation. RESULTS Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps. CONCLUSION It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.
منابع مشابه
Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival
BACKGROUND It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with all...
متن کاملThe Effect of Enoxaparin and Clopidogrel on Survival of Random Skin Flap in Rat Animal Model
BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal ran...
متن کامل[Study of the effect of streptokinase and allopurinol in island skin flaps submitted to prolonged ischemia: experimental study in rats].
BACKGROUND To establish a relation between the survival rate of island skin flaps submitted to prolonged ischemia and the effect of streptokinase and allopurinol administered after the ischemic period. METHODS A total of 48 male Winstar rats, each weighing between 300 and 350 grams,were separated into four groups of twelve as follows: control, allopurinol, streptokinase and association of all...
متن کاملEffects of saffron oral gavage on protection of skin flaps against tissue necrosis and oxidative stress in rats
Introduction: Today, skin flaps are used in many reconstructive surgeries and healing of skin lesions as one of the main methods of treatment. Despite improvements in the fields related to enhancement of skin flap survival, flaps viability and their efficacy are still threatened with issues such as ischemia-reperfusion, oxidative stress, tissue necrosis, and even apoptosis in the affected tissu...
متن کاملاثر آزلائیک اسید 5% و مینوکسیدیل 5% در کاهش ناحیه نکروتیک فلاپهای پوستی در موش صحرای
Backgound and Aim: One important limitation of random pattern skin flap in plastic surgery is the necrosis of distant parts of the flap resulting from ischemia. This effect cause unwanted increase in the costs and hospitalization. Previously, large number of factors has been evaluated to decrease the flap necrosis. In present study we used two drugs. Main reason was their mechanism of action th...
متن کامل